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Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell Tumors

25 Mar 2021

Abstract excerpt

Compared to many common solid tumors, the main genetic drivers of most testicular germ cell tumors (TGCTs) are unknown. Decades of focus on genomic alterations in TGCTs including awareness of a near universal increase in copies of chromosome 12p have failed to uncover exceptional driver genes, especially in genes that can be targeted therapeutically. Thus far, TGCT patients have missed out on the benefits of...

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PMID: 33805941
DOI: 10.3390/cancers13071506

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