Article
Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors.
Oncogene - 30 May 2002
Smiraglia Dominic J, Szymanska Jadwiga, Kraggerud Sigrid M, Lothe Ragnhild A, Peltomäki Päivi, Plass Christoph
Abstract excerpt
The genetic nature of testicular germ cell tumors and the molecular mechanisms underlying the morphological and clinical differences between the two subtypes, seminomas and nonseminomas, remains unclear. Genetic studies show that both subtypes exhibit many of the same regional genomic disruptions, although the frequencies vary and few clear differences are found. We demonstrate significant epigenetic differences...
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