Article

Combined oncolytic adenovirus carrying MnSOD and mK5 genes both regulated by survivin promoter has synergistic inhibitory effect on gastric cancer

2021-04-08

Abstract excerpt

Gastric cancer (GC) is one of the major causes of cancer related mortality. The use of oncolytic virus for cancer gene-virotherapy is a new approach for the treatment of human cancers. In this study, a novel Survivin promoter driven recombinant oncolytic adenovirus carrying mK5 or MnSOD gene was constructed, which was modified after deletion of E1B gene. Human plasminogen Kringle 5 mutant ( mK5 ) and manganese...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6810fd7-3ecd-55f9-b40c-034a5cb8f21a
DOI: 10.1101/2021.04.08.438934

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combined oncolytic adenovirus carrying MnSOD and mK5 genes both regulated by survivin promoter has synergistic inhibitory effect on gastric cancerDOI 10.1101/2021.04.08.438934Read

AdHu5-apoptin induces G2/M arrest and apoptosis in p53-mutated human gastric cancer SGC-7901 cells.Semantic proximity Read

Key points of basic theories and clinical practice in rAd-p53 (Gendicine™) gene therapy for solid malignant tumorsSemantic proximity Read

Increased suppression of oncolytic adenovirus carrying mutant k5 on colorectal tumor.Semantic proximity Read

Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancerSemantic proximity Read

Effects of tumor selective replication-competent herpes viruses in combination with gemcitabine on pancreatic cancer.Semantic proximity Read

Treatment of pancreatic cancer using an oncolytic virus harboring the lipocalin-2 gene.Semantic proximity Read

A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity.Semantic proximity Read

A novel recombinant adenovirus expressing apoptin and MEL genes kills hepatocellular carcinoma cells and inhibits the growth and metastasis of ectopic tumorsSemantic proximity Read

Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo.Semantic proximity Read

Effective Gene-Viral Therapy for Telomerase-Positive Cancers by Selective Replicative-Competent Adenovirus Combining with Endostatin GeneSemantic proximity Read

Augmented therapeutic efficacy of an oncolytic herpes simplex virus type 1 mutant expressing ICP34.5 under the transcriptional control of musashi1 promoter in the treatment of malignant glioma.Semantic proximity Read

Interferon-β-armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells.Semantic proximity Read