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Article

Increased suppression of oncolytic adenovirus carrying mutant k5 on colorectal tumor.

Biochemical and biophysical research communications - 19 Sept 2008

Fan Jun Kai, Xiao Tian, Gu Jin Fa, Wei Na, He Ling Feng, Ding Miao, Liu Xin Yuan

Abstract excerpt

Angiogenesis plays a key role in the development of a wide variety of malignant tumors. The approach of targeting antiangiogenesis has become an important field of cancer gene therapy. In this study, the antiangiogenesis protein K5 (the kringle 5 of human plasminogen) has been mutated by changing leucine71 to arginine to form mK5. Then the ZD55-mK5, which is an oncolytic adenovirus expressing mK5, was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18621025
DOI: 10.1016/j.bbrc.2008.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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