Article

eQTL in diseased colon tissue identifies novel target genes associated with IBD

2024-10-04

Abstract excerpt

<title>Abstract</title> <p>Genome-wide association studies (GWAS) have identified over 300 loci associated with the inflammatory bowel diseases (IBD), but putative causal genes for most are unknown. We conducted the largest disease-focused expression quantitative trait loci (eQTL) analysis using colon tissue from 252 IBD patients to determine genetic effects on gene expression and potential contribution to IBD. C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5027603-96f6-5fe9-94f1-765111995534
DOI: 10.21203/rs.3.rs-5147457/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

eQTL in diseased colon tissue identifies novel target genes associated with IBDDOI 10.21203/rs.3.rs-5147457/v1Read

eQTL in diseased colon tissue identifies novel target genes associated with IBDSemantic proximity Read

eQTL in diseased colon tissue identifies potential target genes associated with IBD.Semantic proximity Read

Characterization of candidate genes in inflammatory bowel disease–associated risk lociSemantic proximity Read

Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association LociSemantic proximity Read

Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci.Semantic proximity Read

Characterization of expression quantitative trait loci in the human colon.Semantic proximity Read

Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine.Semantic proximity Read

Transcriptome-Wide Association Study for Inflammatory Bowel Disease Reveals Novel Candidate Susceptibility Genes in Specific Colon Subsites and Tissue Categories.Semantic proximity Read

Exome sequencing directly implicates 68 genes in inflammatory bowel diseaseSemantic proximity Read

Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease.Semantic proximity Read

Multi-ancestry genome-wide and transcriptome-wide association analyses identified new risk loci and genes for inflammatory bowel diseaseSemantic proximity Read

eQTL analysis links inflammatory bowel disease associated 1q21 locus to ECM1 gene.Semantic proximity Read