Article

Gα <sub>q</sub> modulates the energy metabolism of osteoclasts

2022-04-08

Abstract excerpt

<h4>Summary</h4> The bacterial protein toxin Pasteurella multocida toxin (PMT) mediates RANKL-independent osteoclast differentiation. Although these osteoclasts are small, their resorptive activity is high and destroys the nasal turbinate bones of pigs. Analysis of the proteome of classical and toxin-derived osteoclasts showed that PMT induces the upregulation of metabolic pathways. This includes strong glycolyti...

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Literature Corpus work: b64a556a-fe73-52e9-80b6-cab6db5642bd
DOI: 10.1101/2022.04.06.487374

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