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Article

Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis

15 Jul 2023

Abstract excerpt

The ZAKα-driven ribotoxic stress response (RSR) is activated by ribosome stalling and/or collisions. Recent work demonstrates that RSR also plays a role in innate immunity by activating the human NLRP1 inflammasome. Here, we report that ZAKα and NLRP1 sense bacterial exotoxins that target ribosome elongation factors. One such toxin, diphtheria toxin (DT), the causative agent for human diphtheria, triggers...

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PMID: 37642997
DOI: 10.1084/jem.20230105

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