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Article

Selective Membrane Redistribution and Depletion of Gαq-Protein by Pasteurella multocida Toxin.

Toxins - 1 Aug 2016

Clemons Nathan C, Luo Shuhong, Ho Mengfei, Wilson Brenda A

Abstract excerpt

Pasteurella multocida toxin (PMT), the major virulence factor responsible for zoonotic atrophic rhinitis, is a protein deamidase that activates the alpha subunit of heterotrimeric G proteins. Initial activation of G alpha-q-coupled phospholipase C-beta-1 signaling by PMT is followed by uncoupling of G alpha-q-dependent signaling, causing downregulation of downstream calcium and mitogenic signaling pathways. Here,...

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Identifiers

PMID: 27490568
DOI: 10.3390/toxins8080233
PMCID: PMC4999849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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