Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simvastatin Enhances Muscle Regeneration Through Autophagic Defect-Mediated Inflammation and mTOR Activation in G93ASOD1 Mice.

Molecular neurobiology - 1 Apr 2021

Wang Yafei, Bai Lin, Li Shuai, Wen Ya, Liu Qi, Li Rui, Liu Yaling

Abstract excerpt

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterised by the selective loss of motor neurons, muscular atrophy, and degeneration. Statins, as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are the most widely prescribed drugs to lower cholesterol levels and used for the treatment of cardiovascular and cerebrovascular diseases. However, statins are seldom used in muscular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Denervation
Share to Fibrosis
Share to Muscle Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy

Share to Neuromuscular Junction

Share to Protein Aggregates

Share to Regeneration

Share to Simvastatin

Source

Identifiers

PMID: 33222146
DOI: 10.1007/s12035-020-02216-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simvastatin Enhances Muscle Regeneration Through Autophagic Defect-Mediated Inflammation and mTOR Activation in G93ASOD1 Mice.PMID 33222146Read ↗

Modeling statin-induced myopathy with human iPSCs reveals that impaired proteostasis underlies the myotoxicity and is targetable for the preventionSemantic proximity Read ↗

Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophySemantic proximity Read ↗

“Get the Balance Right”: Pathological Significance of Autophagy Perturbation in Neuromuscular DisordersSemantic proximity Read ↗

Simvastatin Influences Selected Aspects of Duchenne Muscular Dystrophy Pathology in a Mouse ModelSemantic proximity Read ↗

Skeletal Muscle Homeostasis in Duchenne Muscular Dystrophy: Modulating Autophagy as a Promising Therapeutic StrategySemantic proximity Read ↗

Clinical characterization and molecular mechanisms of statin myopathy.Semantic proximity Read ↗

FOXO-regulated DEAF1 controls muscle regeneration through autophagySemantic proximity Read ↗

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset MyopathySemantic proximity Read ↗

Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during agingSemantic proximity Read ↗

Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.Semantic proximity Read ↗

The Role of mTOR in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Autophagy as a new therapeutic target in Duchenne muscular dystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.