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Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function.

American journal of physiology. Endocrinology and metabolism - 1 Feb 2023

Fajardo Lucas, Sanchez Phelipe, Salles Jérôme, Rigaudière Jean Paul, Patrac Véronique, Caspar-Bauguil Sylvie, Bergoglgio Camille, Moro Cédric, Walrand Stéphane, Le Bacquer Olivier

Abstract excerpt

Sarcopenia, the age-related loss of skeletal muscle mass, is associated with lipid accumulation and anabolic resistance; phenomena also observed in obesity and worsen when obesity and aging are combined. The endocannabinoid system (ECS) is overactivated in obesity, but its role in aging obesity-related muscle dysfunction is unknown. The aims of this study were to evaluate the effect of inhibition of the ECS by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36629822
DOI: 10.1152/ajpendo.00258.2022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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