Article

Reprogramming of arachidonate metabolism confers drug resistance to glioblastoma through Enhancing Mitochondrial Activity in Fatty Acid Oxidation

2021-10-18

Abstract excerpt

<title>Abstract</title> <p>Background Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic reprogramming for drug resistance remains unknown. Methods RNA-Seq and mass spectrometry were used to analyze gene expression and metabolites amounts in paired GBM specimens (primary vs. recurrent) and in paired GBM c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b608173f-14d9-586a-a463-9b22f2e25a3b
DOI: 10.21203/rs.3.rs-965026/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reprogramming of arachidonate metabolism confers drug resistance to glioblastoma through Enhancing Mitochondrial Activity in Fatty Acid OxidationDOI 10.21203/rs.3.rs-965026/v1Read

Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment.Semantic proximity Read

Disrupting Pregnane X Receptor Signaling Overcomes Temozolomide Resistance in Glioblastoma via Succisa pratensis–Derived MetabolitesSemantic proximity Read

Advancing glioblastoma treatment by targeting metabolismSemantic proximity Read

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistanceSemantic proximity Read

Temozolomide Treatment Increases Fatty Acid Uptake in Glioblastoma Stem CellsSemantic proximity Read

Multi-Omics Analyses Reveal Mitochondrial Dysfunction Contributing to Temozolomide Resistance in Glioblastoma CellsSemantic proximity Read

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiformeSemantic proximity Read

Autophagy–Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in GliomaSemantic proximity Read

Altered Expression of Carnitine Palmitoyl Transferase 1C (CPT1C) is Related to the Aggressive Pathobiology of Glioblastoma: A Potential Metabolic VulnerabilitySemantic proximity Read

Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastomaSemantic proximity Read

MOGAT3-mediated DAG accumulation drives acquired resistance to anti-BRAF/anti-EGFR therapy in BRAFV600E-mutant metastatic colorectal cancerSemantic proximity Read

Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targetsSemantic proximity Read