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Disrupting Pregnane X Receptor Signaling Overcomes Temozolomide Resistance in Glioblastoma via Succisa pratensis–Derived Metabolites

2026-06-26

Abstract excerpt

Glioblastoma remains a highly aggressive and therapy-resistant brain tumor, with limited benefit from the current standard-of-care regimen combining surgery, radiotherapy, and temozolomide. Overcoming chemoresistance therefore represents a critical unmet clinical need. Here, we investigate the anticancer potential of Succisa pratensis and its ability to enhance TMZ efficacy in GBM models. Treatment with S. prate...

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Literature Corpus work
942e1873-0333-52cc-bde6-7875a60b4bc3
DOI
10.64898/2026.06.22.733681
Open publication

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Disrupting Pregnane X Receptor Signaling Overcomes Temozolomide Resistance in Glioblastoma via Succisa pratensis–Derived MetabolitesDOI 10.64898/2026.06.22.733681
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