Article

A novel pipeline for the validation of manganese chelators for the treatment of manganese overload

2026-05-15

Abstract excerpt

Manganese neurotoxicity, arising from environmental overexposure or inherited transporter disorders due to pathogenic variants in SLC30A10 and SLC39A14, leads to manganism, a debilitating Parkinsonian movement disorder. Alhtough chelation therapy can partially reverse neuropathology, current clinical practice relies on intravenous CaNa2EDTA, which is burdensome and poorly suited for long-term use. Consequently, th...

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Literature Corpus work: b603d55d-31c0-5654-a3b3-aebb90a80b06
DOI: 10.64898/2026.05.12.724311

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