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The Ins and Outs of Manganese: ZIP14 facilitates the efflux of excess manganese from the brain

2025-07-03

Abstract excerpt

Manganese (Mn) is essential for many enzymatic processes in the brain; however, Mn overload can lead to neurotoxicity and behavioral deficits. The blood-brain barrier (BBB), comprised of polarized endothelial cells, tightly regulates metals in and out of the brain. ZIP14 ( SLC39A14 ) is a metal transporter more recently found to transport Mn, with mutations in human SLC39A14 resulting in brain Mn accumulation an...

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Literature Corpus work: 69e50e60-6700-5428-aaea-7e2b5dc34c57
DOI: 10.1101/2025.07.02.662898

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