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Article

Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2020

Aydemir Tolunay B, Thorn Trista L, Ruggiero Courtney H, Pompilus Marjory, Febo Marcelo, Cousins Robert J

Abstract excerpt

Impaired manganese (Mn) homeostasis can result in excess Mn accumulation in specific brain regions and neuropathology. Maintaining Mn homeostasis and detoxification is dependent on effective Mn elimination. Specific metal transporters control Mn homeostasis. Human carriers of mutations in the metal transporter ZIP14 and whole body Zip14-knockout (WB-KO) mice display similar phenotypes, including spontaneous...

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Identifiers

PMID: 32003605
DOI: 10.1152/ajpgi.00301.2019
PMCID: PMC7191460

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