Article

Intestine-specific deletion of metal transporter <i>Zip14 (Slc39a14)</i> causes brain manganese overload and locomotor defects of manganism

2020-01-11

Abstract excerpt

Impaired manganese (Mn) homeostasis can result in excess Mn accumulation in specific brain regions and neuropathology. Maintaining Mn homeostasis and detoxification is dependent on effective Mn elimination. Specific metal transporters control Mn homeostasis. Human carriers of mutations in the metal transporter ZIP14 and whole-body Zip14 KO (WB-KO) mice display similar phenotypes, including spontaneous systemic an...

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Literature Corpus work: 695933c1-92d3-5ffb-a1cf-37ad771bd514
DOI: 10.1101/2020.01.10.902122

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Intestine-specific deletion of metal transporter <i>Zip14 (Slc39a14)</i> causes brain manganese overload and locomotor defects of manganismDOI 10.1101/2020.01.10.902122Read

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