Article

Loss of <i>slc39a14</i> causes simultaneous manganese deficiency and hypersensitivity in zebrafish

2020-01-31

Abstract excerpt

Mutations in SLC39A14, a manganese uptake transporter, lead to a neurodegenerative disorder characterised by accumulation of manganese in the brain and rapidly progressive dystonia-parkinsonism (Hypermanganesemia with Dystonia 2, HMNDYT2). Similar to the human phenotype, zebrafish slc39a14 U801-/- mutants show prominent brain manganese accumulation and abnormal locomotor behaviour. In order to identify novel pot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7891ec58-9f50-5fac-9c68-ee267699bed6
DOI: 10.1101/2020.01.31.921130

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of <i>slc39a14</i> causes simultaneous manganese deficiency and hypersensitivity in zebrafishDOI 10.1101/2020.01.31.921130Read

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.Semantic proximity Read

Hereditary Disorders of Manganese Metabolism: Pathophysiology of Childhood-Onset Dystonia-Parkinsonism in SLC39A14 Mutation Carriers and Genetic Animal Models.Semantic proximity Read

A humanized neuronal model system reveals key roles for manganese in neuronal endocytosis, calcium flux and mitochondrial bioenergeticsSemantic proximity Read

Copper deficiencySemantic proximity Read

Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis.Semantic proximity Read

The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis.Semantic proximity Read

A Novel Role for the Longevity-Associated Protein SLC39A11 as a Manganese TransporterSemantic proximity Read

Atp7a deficiency induces axonal and myelin developmental defects in zebrafish via ferroptosisSemantic proximity Read

Manganese Neurotoxicity: A Comprehensive Review of Pathophysiology and Inherited and Acquired DisordersSemantic proximity Read

Intestine-specific deletion of metal transporter <i>Zip14 (Slc39a14)</i> causes brain manganese overload and locomotor defects of manganismSemantic proximity Read

Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease.Semantic proximity Read

Modeling Lysosomal Storage Diseases in the ZebrafishSemantic proximity Read