Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation.

Cell reports - 27 May 2025

Zaidi Yusra, Tritz Rebekah, Zaidi Nida, Nabi Faisal, Zaidi Syed Adeel H, Morsy Abdelhakim, Harris Valerie, Racine Rilee, Hudson Farlyn Z, Bordan Zsuzsanna, Kennard Simone, Batori Robert, Huo Yuqing, Csanyi Gabor, Belin de Chantemèle Eric J, Lei Kecheng, Boulis Nicholas M, Fulton David J, Khan Rizwan Hasan, Caldwell Ruth B, Stansfield Brian K

Abstract excerpt

Persons with neurofibromatosis type 1 (NF1) exhibit enhanced glucose metabolism, which is replicated in Nf1-mutant mice. Inflammatory macrophages invest NF1-associated tumors, and targeting macrophages appears efficacious in NF1 models. Inflammatory macrophages rely on glycolysis to generate ATP; thus, identifying whether neurofibromin, the protein encoded by NF1, controls glucose metabolism in macrophages is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glucose
Share to Glucose Transporter Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycolysis

Share to Macrophages

Share to Neurofibromatosis 1

Share to Neurofibromin 1

Share to Proto-Oncogene Proteins c-akt

Share to Retinal Neovascularization

Source

Open in PubMed Open full text

Identifiers

PMID: 40279245
DOI: 10.1016/j.celrep.2025.115625
PMCID: PMC12184535

Genes

NF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation.PMID 40279245Read ↗

Loss of Neurofibromin Induces Inflammatory Macrophage Phenotypic Switch and Retinal Neovascularization via GLUT1 ActivationSemantic proximity Read ↗

NF1 deficiency induces metabolic reprogramming and epithelial-mesenchymal transition in glioblastomaSemantic proximity Read ↗

A Patient-Derived Tumoroid Platform for NF1 Low-Grade Glioma shows Myeloid Evolution and Shifting Metabolic Dependencies in vitroSemantic proximity Read ↗

Defining Key Signaling Nodes and Therapeutic Biomarkers in <i>NF1</i> -Mutant CancersSemantic proximity Read ↗

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative RetinopathySemantic proximity Read ↗

Glucose Metabolism Mediates Feedback Control of Innate Immune Signaling in Human MacrophagesSemantic proximity Read ↗

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells.Semantic proximity Read ↗

Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathySemantic proximity Read ↗

NF1germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1Semantic proximity Read ↗

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative RetinopathySemantic proximity Read ↗

Neurofibromin is essential to maintain metabolic function and sustain life in the adult mouseSemantic proximity Read ↗

Metabolic reprogramming controlled by NF-YA alternative splicing creates therapeutic opportunities in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.