Article
Transfection microarrays for high-throughput phenotypic screening of genes involved in cell migration.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Onuki-Nagasaki Reiko, Nagasaki Akira, Hakamada Kazumi, Uyeda Taro Q P, Fujita Satoshi, Miyake Masato, Miyake Jun
Abstract excerpt
Cell migration is important in several biological phenomena, such as cancer metastasis. Therefore, the identification of genes involved in cell migration might facilitate the discovery of antimetastatic drugs. However, screening of genes by the current methods can be complicated by factors related to cell stimulation, for example, abolition of contact inhibition and the release inflammatory cytokines from wounded...
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