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Article

Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis.

Nature communications - 14 Jun 2018

Stoletov Konstantin, Willetts Lian, Paproski Robert J, Bond David J, Raha Srijan, Jovel Juan, Adam Benjamin, Robertson Amy E, Wong Francis, Woolner Emma, Sosnowski Deborah L, Bismar Tarek A, Wong Gane Ka-Shu, Zijlstra Andries, Lewis John D

Abstract excerpt

Metastasis is the most lethal aspect of cancer, yet current therapeutic strategies do not target its key rate-limiting steps. We have previously shown that the entry of cancer cells into the blood stream, or intravasation, is highly dependent upon in vivo cancer cell motility, making it an attractive therapeutic target. To systemically identify genes required for tumor cell motility in an in vivo tumor...

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Identifiers

PMID: 29904055
DOI: 10.1038/s41467-018-04743-2
PMCID: PMC6002534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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