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Article

Inhibition of tumor cell motility by the interferon-inducible GTPase MxA.

The Journal of biological chemistry - 29 May 2009

Mushinski J Frederic, Nguyen Phuongmai, Stevens Lisa M, Khanna Chand, Lee Sunmin, Chung Eun Joo, Lee Min-Jung, Kim Yeong Sang, Linehan W Marston, Horisberger Michel A, Trepel Jane B

Abstract excerpt

To identify pathways controlling prostate cancer metastasis we performed differential display analysis of the human prostate carcinoma cell line PC-3 and its highly metastatic derivative PC-3M. This revealed that a 78-kDa interferon-inducible GTPase, MxA, was expressed in PC-3 but not in PC-3M cells. The gene encoding MxA, MX1, is located in the region of chromosome 21 deleted as a consequence of fusion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19297326
DOI: 10.1074/jbc.M806324200
PMCID: PMC2685701

Genes

ERG
LOX
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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