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Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells

6 Mar 2023

Abstract excerpt

Adoptive cell therapy (ACT) has seen a steep rise of new therapeutic approaches in its immune-oncology pipeline over the last years. This is in great part due to the recent approvals of chimeric antigen receptor (CAR)-T cell therapies and their remarkable efficacy in certain soluble tumors. A big focus of ACT lies on T cells and how to genetically modify them to target and kill tumor cells. Genetically modified T...

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PMID: 36949949
DOI: 10.3389/fimmu.2023.1121030

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