Article
Antigen-scaffolds loaded with hyper-stable neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy.
Frontiers in immunology - 1 Jan 2026
Ormhøj Maria, Munk Kamilla Kjærgaard, Tvingsholm Siri, Ramanathan Keerthana, Bentzen Amalie Kai, Kladis Georgios, Aasbjerg Gitte Nygaard, Nos Grigorii, Tamhane Tripti, Halldórsdóttir Hólmfridur Rósa, Jakobsen Søren Nyboe, Frej Marcus Svensson, Johansen Kristoffer Haurum, Kadivar Mohammad, Hadrup Sine Reker
Abstract excerpt
Introduction: Adoptive cell therapy (ACT) has shown promising results in cancer treatment, however, achieving effective ex vivo expansion of potent, functionally active, and cytotoxic T cells remains challenging. To address this challenge, we recently developed artificial antigen-presenting scaffolds (Ag-scaffolds) capable of expanding antigen-specific T cells with phenotypes favorable for ACT. Here, we compared...
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