Development of zygotic and germline gene drives in mice

Abstract excerpt

CRISPR-based synthetic gene drives have the potential to deliver a more effective and humane method of invasive vertebrate pest control than current strategies. Relatively efficient CRISPR gene drives have been developed in insects and yeast but not in mammals. Here we investigated the efficiency of CRISPR/Cas9-based gene drives in Mus musculus by constructing “split drive” systems with Cas9 under the control of...

Topics

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• CRISPR-Cas Systems
• Gene Editing
• Gene Knockout Techniques
• Gene Order
• Gene Targeting
• Genotyping Techniques
• RNA, Guide, CRISPR-Cas Systems
• Zygote

Identifiers and source

Literature Corpus work

b58a4297-632d-5e3a-8407-1a13bcfc64e3

DOI

10.1101/2020.06.21.162594