Article

Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells

2025-09-16

Abstract excerpt

Drosophila male germline stem cells (GSCs) reside at the testis tip, surrounding a cluster of niche cells known as the hub. Bone Morphogenetic Protein (BMP) ligands secreted from the hub exert both contact-dependent and -independent effects. In close proximity to the niche, BMP signaling maintains stem cells by suppressing transcription of the key differentiation factor Bag of Marbles (Bam). In contrast, the diffu...

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Literature Corpus work: b5879533-a2f0-5970-b19e-67802e1873be
DOI: 10.1101/2025.09.14.676154

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