Article
Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue.
Science (New York, N.Y.) - 21 Dec 2001
Kiger A A, Jones D L, Schulz C, Rogers M B, Fuller M T
Abstract excerpt
Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal...
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