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Article

The niche-dependent feedback loop generates a BMP activity gradient to determine the germline stem cell fate.

Current biology : CB - 20 Mar 2012

Xia Laixin, Zheng Xiudeng, Zheng Wenjing, Zhang Guoqiang, Wang Hailong, Tao Yi, Chen Dahua

Abstract excerpt

Stem cells interact with surrounding stromal cells (or niche) via signaling pathways to precisely balance stem cell self-renewal and differentiation. However, little is known about how niche signals are transduced dynamically and differentially to stem cells and their intermediate progeny and how the fate switch of stem cell to differentiating cell is initiated. The Drosophila ovarian germline stem cells (GSCs)...

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Source

Identifiers

PMID: 22365848
DOI: 10.1016/j.cub.2012.01.056

Genes

GSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The niche-dependent feedback loop generates a BMP activity gradient to determine the germline stem cell fate.PMID 22365848Read ↗

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