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Mechanisms of life cycle simplification in African trypanosomes.

Nature communications - 2 Dec 2024

Oldrieve Guy R, Venter Frank, Cayla Mathieu, Verney Mylène, Hébert Laurent, Geerts Manon, Van Reet Nick, Matthews Keith R

Abstract excerpt

African trypanosomes are important parasites in sub-Saharan Africa that undergo a quorum-sensing dependent development to morphologically 'stumpy forms' in mammalian hosts to favour transmission by tsetse flies. However, some trypanosome clades have simplified their lifecycle by escaping dependence on tsetse allowing an expanded geographic range, with direct transmission between hosts achieved via blood-feeding...

Topics

Life Cycle Stages
Animals
Trypanosoma brucei brucei
Trypanosomiasis, African
Tsetse Flies
Protozoan Proteins
Mutation
Humans
Chiroptera

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39622840
DOI: 10.1038/s41467-024-54555-w
PMCID: PMC11612274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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