Article
Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits.
PLoS genetics - 1 Jul 2017
Crawford Lorin, Zeng Ping, Mukherjee Sayan, Zhou Xiang
Abstract excerpt
Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants. However, because of the large combinatorial search space of interactions, most epistasis mapping methods face enormous computational challenges and often suffer...
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