Differential regulation of BAX and BAK apoptotic activity revealed by a novel small molecule

Abstract excerpt

Defective apoptosis mediated by BAK or BAX underlies various human pathologies including autoimmune and degenerative conditions. The mitochondrial channel protein VDAC2 interacts with BAK and BAX through a common interface to either inhibit BAK or to facilitate BAX apoptotic activity. Using a newly developed small molecule (WEHI-3773) that inhibits the interaction between VDAC2 and BAK or BAX, we reveal contrastin...

Topics

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• bcl-2-Associated X Protein
• bcl-2 Homologous Antagonist-Killer Protein
• Bcl-2-Like Protein 11
• BH3 Interacting Domain Death Agonist Protein
• Cancer-related Molecular Pathways
• Cell death mechanisms and regulation
• Etoposide
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

b5432de3-0227-5c9d-82e9-0d107d24653b

DOI

10.1101/2024.08.04.605933