Article

Toward Targeting Antiapoptotic MCL-1 for Cancer Therapy

2019-11-25

Abstract excerpt

Apoptosis is critical for embryonic development, tissue homeostasis, and the removal of infected or otherwise dangerous cells. It is controlled by three subgroups of the BCL-2 protein family—the BH3-only proteins that initiate cell death; the effectors of cell killing, BAX and BAK; and the antiapoptotic guardians, including MCL-1 and BCL-2. Defects in apoptosis can promote tumorigenesis and render malignant cells...

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Identifiers and source

Literature Corpus work: 04a250bb-c650-56c1-b991-eb54a4dfcca9
DOI: 10.1146/annurev-cancerbio-030419-033510

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