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The BCL-2 arbiters of apoptosis and their growing role as cancer targets

3 Nov 2017

Abstract excerpt

Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepening understanding of how opposing factions of the BCL-2 protein family switch on apoptosis and of their structures has driven development of a new class of cancer drugs that targets various pro-survival members by mimicking their natural inhibitors, the BH3-only proteins. These 'BH3...

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PMID: 29099483
DOI: 10.1038/cdd.2017.161

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