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Spatial Transcriptomic Analysis Identifies a <i>SERPINA3</i> -Expressing Astrocytic State Associated with the Human Neuritic Plaque Microenvironment

2024-11-14

Abstract excerpt

Single-nucleus transcriptomic studies have revealed glial cell states associated with Alzheimer’s disease; however, these nuclei are dissociated from the complex architecture of the human neocortex. Here, we successfully performed an unbiased distance-based analytic strategy on spatially-registered transcriptomic data. Leveraging immunohistochemistry in the same tissue section, our analyses prioritized SERPINA3 a...

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Literature Corpus work
50f5916e-db7e-5a6c-8785-409964bc906b
DOI
10.1101/2024.11.13.623438
Open publication

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Spatial Transcriptomic Analysis Identifies a <i>SERPINA3</i> -Expressing Astrocytic State Associated with the Human Neuritic Plaque MicroenvironmentDOI 10.1101/2024.11.13.623438
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