Fly Models of Human Diseases: Drosophila as a Model for Understanding Human Mitochondrial Mutations and Disease.

doi:10.1016/bs.ctdb.2016.07.001

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Article

Fly Models of Human Diseases: Drosophila as a Model for Understanding Human Mitochondrial Mutations and Disease.

Current topics in developmental biology - 1 Jan 2017

Sen A, Cox R T

Abstract excerpt

Mitochondrial diseases are a prevalent, heterogeneous class of diseases caused by defects in oxidative phosphorylation, whose severity depends upon particular genetic mutations. These diseases can be difficult to diagnose, and current therapeutics have limited efficacy, primarily treating only symptoms. Because mitochondria play a pivotal role in numerous cellular functions, especially ATP production, their...

Topics

Animals
Base Sequence
DNA, Mitochondrial
Disease Models, Animal
Drosophila
Humans
Mitochondria
Mitochondrial Diseases
Mutation

Source

Open in PubMed

Identifiers

PMID: 28057297
DOI: 10.1016/bs.ctdb.2016.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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