Article
eQTL in diseased colon tissue identifies potential target genes associated with IBD.
Nature communications - 13 Feb 2026
Nishiyama Nina C, Silverstein Sophie, Darlington Kimberly, Kennedy Ng Meaghan M, Clough Katelyn M, Bauer Mikaela, Beasley Caroline, Bharadwaj Akshatha, Ganesan Rajee, Kapadia Muneera R, Lau Gwen, Lian Grace, Rahbar Reza, Sadiq Timothy S, Schaner Matthew R, Stem Jonathan, Friton Jessica, Faubion William A, Sheikh Shehzad Z, Furey Terrence S
Abstract excerpt
Genome-wide association studies (GWAS) have identified over 300 loci associated with the inflammatory bowel diseases (IBD), but putative causal genes for most loci are unknown. We conducted a disease-focused expression quantitative trait loci (eQTL) analysis using colon tissue from 252 IBD patients. We hypothesized IBD tissue could uncover IBD-associated regulatory variation undetectable in non-IBD cohorts. Here...
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