Article

The KDM6 histone demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells

2024-12-28

Abstract excerpt

<h4>ABSTRACT</h4> Thioneins are cysteine-rich apoproteins that regulate divalent metal homeostasis by virtue of their metal-chelation properties resulting in the ligand-bound metallothionein state. Previous studies show transient upregulation of the metallothionein (MT) gene cluster as part of a complex transcriptional response to a class of histone demethylase tool compounds targeting human Fe 2+ dependent keto...

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Literature Corpus work: b50014c4-9cd8-524e-a5f4-623f8c3dac17
DOI: 10.1101/2024.12.28.630531

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