Article

<i>SOD1</i> is a synthetic lethal target in <i>PPM1D</i> -mutant leukemia cells

2023-09-01

Abstract excerpt

The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D) is a master negative regulator of the response; gain-of-function mutations and amplifications of PPM1D are found across several human cancers making it a relevant pharmacologic target. Here, we used CRISPR/Cas9 screening to identify synthe...

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Literature Corpus work: bbc35d1e-411b-51c2-9f6d-1d440e3bc058
DOI: 10.1101/2023.08.31.555634

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