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Article

Therapeutic implications of mitochondrial stress–induced proteasome inhibitor resistance in multiple myeloma

28 Sept 2022

Abstract excerpt

The connections between metabolic state and therapy resistance in multiple myeloma (MM) are poorly understood. We previously reported that electron transport chain (ETC) suppression promotes sensitivity to the BCL-2 antagonist venetoclax. Here, we show that ETC suppression promotes resistance to proteasome inhibitors (PIs). Interrogation of ETC-suppressed MM reveals integrated stress response–dependent...

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PMID: 36170375
DOI: 10.1126/sciadv.abq5575

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