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Article

Transition from Transient DNA Rereplication to Inherited Gene Amplification Following Prolonged Environmental Stress

2023-05-09

Abstract excerpt

<h4>ABSTRACT</h4> Cells require the ability to adapt to changing environmental conditions, however, it is unclear how these changes elicit stable permanent changes in genomes. We demonstrate that, in response to environmental metal exposure, the metallothionein (MT) locus undergoes DNA rereplication generating transient site-specific gene amplifications (TSSGs). Chronic metal exposure allows transition from MT TS...

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Literature Corpus work
71966fb5-9cca-5fbf-8013-595877e420c6
DOI
10.1101/2023.05.08.539886
Open publication

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Transition from Transient DNA Rereplication to Inherited Gene Amplification Following Prolonged Environmental StressDOI 10.1101/2023.05.08.539886
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