Article
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells.
eLife - 18 Jun 2024
Zhang Linda, Hsu Joanne I, Braekeleer Etienne D, Chen Chun-Wei, Patel Tajhal D, Martell Alejandra G, Guzman Anna G, Wohlan Katharina, Waldvogel Sarah M, Uryu Hidetaka, Tovy Ayala, Callen Elsa, Murdaugh Rebecca L, Richard Rosemary, Jansen Sandra, Vissers Lisenka, de Vries Bert B A, Nussenzweig Andre, Huang Shixia, Coarfa Cristian, Anastas Jamie, Takahashi Koichi, Vassiliou George, Goodell Margaret A
Abstract excerpt
The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase Mg2+/Mn2+-dependent 1D) is a master negative regulator of the response; gain-of-function mutations and amplifications of PPM1D are found across several human cancers making it a relevant pharmacological target. Here, we used CRISPR/Cas9 screening to identify...
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