Article

Hydrogen sulfide binds to the catalytic zinc ion in HDAC6 to modulate enzyme activity via an alternative deacetylation pathway

2026-01-12

Abstract excerpt

<title>Abstract</title> <p>The present study aims to examine if a tiny gas molecule, hydrogen sulfide (H2S), directly binds to the catalytic zinc ion of histone deacetylase 6 (HDAC6) to regulate enzyme activity via a mechanism beyond the post-translational modifications (PTMs) theory. H2S was found to coordinate with the catalytic metal ions in a series of metalloenzymes centered by zinc, ferrum, calcium, mangane...

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Identifiers and source

Literature Corpus work: df859042-27ac-5633-b189-87b6e97d7e4b
DOI: 10.21203/rs.3.rs-777997/v1

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