Structural models of full-length JAK2 kinase

Abstract excerpt

The protein JAK2 is a prototypical member of the Janus kinase family, and mediates signals from numerous cytokine receptors. The constitutively active V617F mutant of JAK2 is prevalent in many bone marrow disorders, blood cancers, and autoimmune diseases, and is an important drug target. Structures have been determined for each of the four individual domains making up JAK2, and for certain pairs of these domains,...

Topics

Open a Topic to create a Post that cites this publication.

• Enzyme Activation
• Enzyme Stability
• Janus Kinase 2
• Models, Molecular
• Molecular Structure
• Protein Binding
• Protein Conformation
• Protein Structure, Tertiary

Identifiers and source

Literature Corpus work

b4f28d5c-6910-5db8-ad0b-201a03abd2a4

DOI

10.1101/727727