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Article

Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations.

BMC structural biology - 10 Sept 2009

Lee Tai-Sung, Ma Wanlong, Zhang Xi, Kantarjian Hagop, Albitar Maher

Abstract excerpt

BACKGROUND: The functional relevance of many of the recently detected JAK2 mutations, except V617F and exon 12 mutants, in patients with chronic myeloproliferative neoplasia (MPN) has been significantly overlooked. To explore atomic-level explanations of the possible mutational effects from those...

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Identifiers

PMID: 19744331
DOI: 10.1186/1472-6807-9-58
PMCID: PMC2749040

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19744331-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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