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Article

Regulation of JAK2 activation by Janus homology 2: evidence from molecular dynamics simulations.

Journal of chemical information and modeling - 26 Nov 2012

Wan Shunzhou, Coveney Peter V

Abstract excerpt

Janus kinase 2 (JAK2) is a protein tyrosine kinase implicated in signaling by specific members of the cytokine receptor family. Although it has been established that the JAK2 tyrosine kinase is negatively regulated by the JAK homology 2 (JH2) pseudokinase domain, the underlying mechanism of JH2 mediated regulation remains elusive. To elucidate the regulation of JAK2 kinase, we have built a structural model for...

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Source

Identifiers

PMID: 23033920
DOI: 10.1021/ci300308g

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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