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Article

Crystal Structure of the FERM-SH2 Module of Human Jak2.

PloS one - 1 Jan 2016

McNally Randall, Toms Angela V, Eck Michael J

Abstract excerpt

Jak-family tyrosine kinases mediate signaling from diverse cytokine receptors. Binding of Jaks to their cognate receptors is mediated by their N-terminal region, which contains FERM and SH2 domains. Here we describe the crystal structure of the FERM-SH2 region of Jak2 at 3.0Å resolution. The structure reveals that these domains and their flanking linker segments interact intimately to form an integrated...

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Identifiers

PMID: 27227461
DOI: 10.1371/journal.pone.0156218
PMCID: PMC4881981

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