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Article

New insights into the structure and function of the pseudokinase domain in JAK2.

Biochemical Society transactions - 1 Aug 2013

Silvennoinen Olli, Ungureanu Daniela, Niranjan Yashavanthi, Hammaren Henrik, Bandaranayake Rajintha, Hubbard Stevan R

Abstract excerpt

JAK (Janus kinase) 2 plays a critical role in signal transduction through several cytokine receptors. JAKs contain a typical tyrosine kinase domain preceded by a pseudokinase [JH2 (JAK homology 2)] domain which has been considered to be catalytically inactive. Identification of activating mutations in the JH2 domain of JAK2 as the major cause for polycythaemia vera and other MPNs (myeloproliferative neoplasms)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23863170
DOI: 10.1042/BST20130005

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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New insights into the structure and function of the pseudokinase domain in JAK2.PMID 23863170Read ↗

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