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Article

The effects of R683S (G) genetic mutations on the JAK2 activity, structure and stability.

International journal of biological macromolecules - 1 Sept 2013

Li Feng, Guo Hua-Yan, Wang Man, Geng Hong-Li, Bian Mei-Ru, Cao Jiang, Chen Chong, Zeng Ling-Yu, Wang Xiao-Yun, Wu Qing-Yun

Abstract excerpt

Janus kinase 2 (JAK2) is an important mediator of cytokine receptor signaling and plays key roles in the hematopoietic and immune response. The acquired JAK2 R683S (G) mutations are presumed to be a biomarker for B-cell acute lymphoblastic leukemia (B-ALL). However, how these mutations leading to the B-ALL is still unclear. The crystal structure of JAK2 JH2 domain suggests that the residue R683 locating in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23748007
DOI: 10.1016/j.ijbiomac.2013.05.029

Genes

JAK2

Variants

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