Article

Underlying causes for prevalent false positives and false negatives in STARR-seq data

2023-03-03

Abstract excerpt

STARR-seq and its variants have been widely used to characterize enhancers. However, it has been reported that up to 87% of STARR peaks are located in repressive chromatins and are not functional in the tested cells. While some of the STARR peaks in repressive chromatins might be active in other cell/tissue types, some others might be false positives. Meanwhile, many active enhancers may not be identified by the c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4e74949-9c43-5224-8adb-e56c46f795dd
DOI: 10.1101/2023.03.03.530915

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Underlying causes for prevalent false positives and false negatives in STARR-seq dataDOI 10.1101/2023.03.03.530915Read

STARRPeaker: Uniform processing and accurate identification of STARR-seq active regionsSemantic proximity Read

High-resolution dissection of human cell type-specific enhancers in <i>cis</i> and <i>trans</i> activitiesSemantic proximity Read

Comprehensive Evaluation of Diverse Massively Parallel Reporter Assays to Functionally Characterize Human Enhancers Genome-wideSemantic proximity Read

Mammalian enhancers and GWASs act proximally and seldom skip active genesSemantic proximity Read

An atlas of silencer elements for the human and mouse genomesSemantic proximity Read

Super-enhancers are transcriptionally more active and cell-type-specific than stretch enhancersSemantic proximity Read

Cis-Regulatory Atlas in Primary Human CD4+ T CellsSemantic proximity Read

An atlas of active enhancers across human cell types and tissues.Semantic proximity Read

An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional RegulationSemantic proximity Read

Super-enhancers in the control of cell identity and disease.Semantic proximity Read

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cellsSemantic proximity Read

What are super-enhancers?Semantic proximity Read