Article

Germline-somatic residue synergy reshapes antibody encounter-state pathways to enhance HIV-1 recognition

2026-03-27

Abstract excerpt

Antibodies initiate antigen recognition through short-lived encounter states. These states are structurally distinct from the bound state and allow an antibody to reach the epitope from diverse approach angles. We previously showed that encounter states enable broadly neutralizing HIV-1 antibodies to access protected epitopes, but how these states evolve during affinity maturation is unknown. Here, we defined enco...

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Literature Corpus work: b4d0276c-126a-58c6-8fa0-e60ba8567dd1
DOI: 10.64898/2026.03.26.714541

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