Article

Integrin αM promotes macrophage alternative M2 polarization in hyperuricemia-related chronic kidney disease

2023-01-03

Abstract excerpt

<h4>Background: </h4> and purpose: Hyperuricemia is an essential risk factor in chronic kidney disease (CKD), while urate-lowering therapy to prevent or delay CKD progression is controversial. Alternatively activated macrophages in response to local microenvironment play diverse roles in kidney injury, repair, and fibrosis. Here, we aim to investigate whether and how macrophage ITGAM contributes to hyperuricemia-r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95c9cb54-6760-5e10-bcf2-52d1fc8834bf
DOI: 10.22541/au.167271498.81107792/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrin αM promotes macrophage alternative M2 polarization in hyperuricemia-related chronic kidney diseaseDOI 10.22541/au.167271498.81107792/v1Read

Spatial analysis reveals the cellular microenvironments and mechanisms of inflammation and kidney injury in acute interstitial nephritisSemantic proximity Read

Single-cell transcriptome analysis reveals status changes of immune cells in chronic kidney diseaseSemantic proximity Read

Single-cell transcriptomic profiling of kidney fibrosis identifies a novel specific fibroblast marker and putative disease targetSemantic proximity Read

Resident macrophage subpopulations occupy distinct microenvironments in the kidneySemantic proximity Read

Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathySemantic proximity Read

The renal response to FGF23 shifts from phosphaturia towards inflammation in kidney diseaseSemantic proximity Read

Integrated single-nucleus sequencing and spatial architecture analysis identified distinct injured-proximal tubular types in calculi ratsSemantic proximity Read

The role of macrophages in fibrosis of chronic kidney disease.Semantic proximity Read

Integrative Transcriptomic Analysis Implicates Platelet Activation as a Potential Pathological Mechanism in IgA Nephropathy: Evidence from Multi-Dataset Analysis and Urinary Biomarker ValidationSemantic proximity Read

APC and ZBTB2 may mediate M2 macrophage infiltration to promote the development of renal fibrosis: Bioinformatics AnalysisSemantic proximity Read

Macrophages in the kidney in health, injury and repair.Semantic proximity Read

Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophagesSemantic proximity Read